Evolve a Cell Mutations: What's Confirmed, How to Roll, and What's Still Unknown

If you've been farming DNA and wondering what comes after the evolution tree, Evolve a Cell mutations are the next layer of progression — and the least documented one. Parts like jaws and tails are visible the moment you open the evolve menu, but most Evolve a Cell mutations have never been officially named, listed, or priced. Below is what the available sources actually confirm, what is still just a community report, and how to approach rolling once you reach that stage.

What Are Evolve a Cell Mutations?

Mutations sit at the far end of the progression chain in Evolve a Cell on Roblox. Current community coverage tied to gameplay footage reports that Rebirth unlocks at Stage 4 and opens the Mutations screen, where mutations are rolled for passive bonuses. Published community coverage now names at least the Rare slick membrane mutation and reports its effect; a complete mutation list, exact reroll prices, and roll odds remain unverified.

The official Roblox page doesn't mention mutations at all. Its description focuses on the core loop: eat plants or hunt other cells (including players), attach jaws, spikes, eyes, and tails, shape and paint your creature, and grow huge enough to take down giant bosses. The game is tagged Simulation / Incremental Simulator, with a 16-player server size and an "inspired by Spore" note.

So if you're hunting for a full Evolve a Cell mutations tier list, the honest answer is that no verifiable complete list exists yet. Current community coverage includes at least the player-reported Void entry and a Rare slick membrane example.

Published Mutation Examples: Void and Slick Membrane

The independent fan wiki's mutation hub lists exactly one entry with a player-reported name and effect. Everything else in the rare list is described as unpublished.

Two caveats matter here. First, this is one player's description of one effect — not a developer confirmation, and not something multiple players have independently verified. Second, the wiki's own FAQ says the mutation list is longer than that: a player reported missing "one rare mutation and the mythic." That phrasing implies a rare tier with more than one entry plus a separate mythic tier, but no names or effects for those entries have been published anywhere in the supplied sources.

In practical terms, treat Void as "reported, plausible, unconfirmed." Don't reroll blindly chasing a specific mutation based on a single account.

How Mutations Fit Into the Progression Ladder

The same creator guide that mentions rolling also lays out the path that leads there. It's a useful checklist because mutations are gated behind everything else:

1. Pick your diet. Meat lets you collect red food and attack other cells for extra XP; plants focus you on green food.
2. Farm XP and DNA. Eating and defeating smaller cells levels you up and unlocks upgrades.
3. Grab movement and survival parts early. The guide recommends flagellum for speed, lure to pull food toward you, and jaws for offense, while thick membrane and hard shell keep you alive.
4. Check quests separately. Quests in the upper-left corner are reported to award progression points and rewards; current evidence does not show that these are Evolution Tree points.
5. Roll mutations last. Only after you can survive fights does the guide suggest experimenting with stronger offensive parts and mutations.

Reported upgrade values from that guide:

These are creator-guide figures, not datamined values, so treat them as close approximations rather than exact constants.

Parts, Evolution Tree, and Mutations: Three Separate Systems

New players often conflate these, and it's worth separating them before you spend anything.

Parts are the most transparent layer — the official description confirms you can add jaws, spikes, eyes, and tails, and the guide notes horns hit hard on a dash, drill damages on contact, and tentacle strikes nearby targets for several seconds. The evolution tree is a passive layer. Mutations appear to be the layer that can change how an ability behaves, which is exactly what the Void report describes.

Tips for Rolling Mutations Without Losing a Run

• Don't chase mutations before you can fight. The guide's core advice is to build something that survives first, then experiment.
• Avoid cells much larger than yours, especially apex predators — they can end a run almost instantly.
• Watch for green clouds and defensive attacks from other cells, not just direct aggression.
• Know your death options. Gameplay-based coverage reports Descendant (continue as generation 2, keeping part of your design), Start over (reset to stage 0), and Second chance (a Robux revive that keeps everything on the spot).
• Log what you roll. With no verified complete mutation list, your own notes are still useful for tracking what you roll.

Evolve a Cell at a Glance: Dated Snapshots

Player counts and ratings move constantly, so the figures below are frozen at the moment each page was captured, not live values.

The official page also listed a 10/14/2026 update and a server size of 16 at that capture. For live numbers, check the sources directly — those snapshots describe one morning, not the present.

FAQ

How many mutations are in Evolve a Cell? Nobody has published a confirmed total. The fan wiki's mutation hub contains one named entry (Void), and its FAQ states that only Void has a player-reported name and effect while the rest of the rare list is unknown. A player quoted there mentioned missing one rare mutation and the mythic, which suggests more entries exist than have been documented.

What does the Void mutation do? According to a single player report collected by the wiki, Void is a mythic that replaces your dash with a teleport roughly every 12 seconds. That effect has not been independently confirmed, so verify it in-game before building a strategy around it.

Are Evolve a Cell mutations stronger than parts? They aren't really comparable. Parts are attachable and visible — jaws, horns, drill, tentacle, tails, eyes — and the evolution tree grants passive bonuses. Mutations reportedly add rolled bonuses on top, with at least one apparently altering an ability. No supported ranking exists.

When do you unlock mutations? Current community coverage tied to gameplay footage reports that mutations unlock with Rebirth at Stage 4; it does not establish a DNA threshold. Focus on XP, DNA, quests, and survival upgrades first, and treat mutations as the payoff for a run you can already sustain.